Clinical Research Directory

Inclusion Criteria: * • Patient age must be between 18-50 years * Must be able to give written informed consent * Must have systemic status (ASA 1) * Must have mature permanent molar or premolar (lower upper) * Must be symptomatic (spontaneous pain - mild to severe), extremely deep (D4) carious teeth * Must have pulp exposure in non-selective carious cleaning procedure * Must have vital response in cold test and electric pulp test * Must have no periodontal disease * Must have restorable teeth * Must have teeth without pulp necrosis, sinus tract or swelling/abscess * Must have bleeding time less than 10 minutes * Maximum two teeth in a patient must be included in the study (must be in different quadrants and must have at least 2 weeks between treatment periods) Exclusion Criteria: * Teeth with incomplete root development * Teeth without symptoms of irreversible pulpitis * Severely affected teeth that do not respond to pulp sensitivity tests * Teeth without signs of bleeding after exposure with the pulp chamber * Teeth with pulp chamber open to the oral environment * Teeth with periodontal pockets greater than 4 mm deep * Teeth with suspected cracks or crown fractures that may be responsible for pulp pathology * Teeth with uncontrolled bleeding * Medically risky patients will be excluded from the study.