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Pilot Trial of Colchicine for Graft Failure in CABG
Sponsor: Ruijin Hospital
Summary
The goal of this pilot trial is to to evaluate the preliminary effect of oral colchicine therapy on graft outcomes in patients underwent primary isolated CABG. The main questions it aims to answer is: 1. Whether the oral colchicine therapy may reduce the failure outcome of grafts after CABG. 2. Whether it is feasible to construct a muticenter powered trial to test the superiority hypothesis. Researchers will compare colchicine to none to see if colchicine works. Participants will 1. Take oral colchicine (0.5mg daily) therapy for 12 months after CABG. 2. Clinical follow-up at Month 1, 6, and 12 after CABG. 3. Protocol-driven CCTA at Week 1 and Month 12 after CABG.
Official title: A Single Center Pilot Trial of Preliminary Effect of Colchicine on Graft Failure in Patients Underwent CABG
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2025-12-29
Completion Date
2028-12
Last Updated
2026-01-02
Healthy Volunteers
No
Conditions
Interventions
Colchicine
Oral Colchicine 0.5mg qd for 1 year
Locations (1)
Ruijin Hospital Shanghai Jiao Tong University School of Medicine
Shanghai, China