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Interest of Sperm Insemination at 42 Hours Post hCG Compared to 36h in Intrauterine Insemination
Sponsor: University Hospital, Toulouse
Summary
Intrauterine insemination (IUI) is a common therapeutic option to treate infertility. Typically performed 36 hours post-hCG injection to trigger ovulation. However, research suggests delaying IUI to 42 hours post-hCG may improve egg quality and sperm synchronization for fertilization, leading to higher pregnancy rates. A proposed superiority study aims to compare IUI timing at 36 hours versus 42 hours post-hCG injection to evaluate its impact on live birth rates. The primary objective is to assess the effectiveness (live birth rates) of IUI at two different post-hCG timing intervals (42-43 hours vs 36-37 hours).
Official title: Interest of Sperm Insemination at 42 Hours Post hCG Compared to 36h in Intrauterine Insemination : a Randomized Controlled Trial. SYNcIU
Key Details
Gender
FEMALE
Age Range
18 Years - 43 Years
Study Type
INTERVENTIONAL
Enrollment
692
Start Date
2025-09-09
Completion Date
2028-12-01
Last Updated
2025-09-12
Healthy Volunteers
No
Interventions
Insemination between 42 and 43 hours post hCG
Patients will be stimulated by gonadotropins, ovulation will be blocked by a GnRH antagonist then triggered by hCG allowing IU to occur between 42 and 43 hours post hCG
Insemination between 36 and 37 hours post hCG
Patients will be stimulated with gonadotropin and GnRH antagonist whose ovulation will be triggered and for which intrauterine insemination will be carried out between 36 and 37 hours post hCG
Locations (4)
CHU Bordeaux
Bordeaux, France
CHU La Réunion
La Réunion, France
CHU Poitiers
Poitiers, France
CHU Toulouse
Toulouse, France