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RECRUITING
NCT06804538
NA

Interest of Sperm Insemination at 42 Hours Post hCG Compared to 36h in Intrauterine Insemination

Sponsor: University Hospital, Toulouse

View on ClinicalTrials.gov

Summary

Intrauterine insemination (IUI) is a common therapeutic option to treate infertility. Typically performed 36 hours post-hCG injection to trigger ovulation. However, research suggests delaying IUI to 42 hours post-hCG may improve egg quality and sperm synchronization for fertilization, leading to higher pregnancy rates. A proposed superiority study aims to compare IUI timing at 36 hours versus 42 hours post-hCG injection to evaluate its impact on live birth rates. The primary objective is to assess the effectiveness (live birth rates) of IUI at two different post-hCG timing intervals (42-43 hours vs 36-37 hours).

Official title: Interest of Sperm Insemination at 42 Hours Post hCG Compared to 36h in Intrauterine Insemination : a Randomized Controlled Trial. SYNcIU

Key Details

Gender

FEMALE

Age Range

18 Years - 43 Years

Study Type

INTERVENTIONAL

Enrollment

692

Start Date

2025-09-09

Completion Date

2028-12-01

Last Updated

2025-09-12

Healthy Volunteers

No

Interventions

PROCEDURE

Insemination between 42 and 43 hours post hCG

Patients will be stimulated by gonadotropins, ovulation will be blocked by a GnRH antagonist then triggered by hCG allowing IU to occur between 42 and 43 hours post hCG

PROCEDURE

Insemination between 36 and 37 hours post hCG

Patients will be stimulated with gonadotropin and GnRH antagonist whose ovulation will be triggered and for which intrauterine insemination will be carried out between 36 and 37 hours post hCG

Locations (4)

CHU Bordeaux

Bordeaux, France

CHU La Réunion

La Réunion, France

CHU Poitiers

Poitiers, France

CHU Toulouse

Toulouse, France