Clinical Research Directory

Inclusion Criteria: * 1\. Male and female volunteers, 18-65 years old * 2\. Willing to provide informed consent * 3\. Willing and able to follow instructions for ARM procedure Exclusion Criteria: * 1\. Documented history of gastrointestinal disorders such as: * a. fecal incontinence, * b. irritable bowel syndrome (IBS), * c. functional constipation, as defined by two or more of these symptoms for at least 25% of the time over the past 3 months: * i. excessive straining, * ii. hard or lumpy stools, * iii. sensation of incomplete evacuation, * iv. a feeling of anorectal blockage, * v. manual maneuvers to facilitate defecation, * vi. or fewer than 3 bowel movements per week. * d. functional diarrhea, as defined by the following symptoms over the past 3 months: * i. Loose or watery stools * ii. Lack of pain with diarrhea * iii. Diarrhea occurring in at least 75% of bowel movements * iv. No identifiable causes * 2\. Use of medications that may affect gastrointestinal motility as determined by healthcare professional. * 3\. Prior pelvic radiation, * 4\. Prior anorectal surgical procedures, including treatment for hemorrhoids, * 5\. Risk factors for pelvic floor trauma: * a. more than 4 vaginal deliveries, * b. vaginal delivery with birthweight greater than 4500gms (macrosomia), * c. known 4th degree perineal tear or known forceps use during delivery. * 6\. Contraindicated for ARM testing * 7\. Has gastrointestinal symptoms and is indicated for ARM testing * 8\. Subject is currently pregnant or plans to become pregnant during the course of their enrollment in the study, as self-reported.