Clinical Research Directory

Inclusion Criteria: 1. Age ≥18 and ≤ 70 years presumed or known 2. Witnessed OHCA 3. Bystander CPR provided 4. Presumed cardiac or unknown cause 5. An initial documented shockable rhythm of VF (ventricular fibrillation) or pulseless VT (ventricular tachycardia) 6. Minimum of ≥ 10 min of ACLS without ROSC or at least ≥ 3 defibrillations in ongoing VF/pulseless VT 7. Body morphology able to accommodate a mechanical chest compression device 8. ECPR team and intensive care unit (ICU) capacity in the receiving center available 9. Estimated transfer time from the scene to the hospital ≤ 30 minutes or to the scene ≤ 30 minutes 10. Eligible for intensive care without restrictions or limitations Exclusion Criteria: 1. ACLS ≥ 30 minutes before randomization 2. Known limitations in care or a Do Not Attempt to Resuscitate (DNAR) order 3. Known severe disease making 90-day survival unlikely 4. Known bleeding diathesis or acute or recent intracranial bleeding 5. Known, obvious or suspected pregnancy 6. Known pre-arrest severe cognitive dysfunction (mRS ≥ 4) 7. Known hypothermia as a cause of cardiac arrest