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Hyperbaric Oxygen Therapy on Insulin Resistance in Postmenopause
Sponsor: Cairo University
Summary
Background: In postmenopausal females, Insulin resistance is commonly encountered in clinical setting. Hyperbaric oxygen therapy have been proposed effective in lowering blood glucose level and improving function. Identification of clinical examination variables as predictors to blood glucose levels and dysfunction would offer therapists the chance to undertake clinical decisions and consequently improve treatment efficiency. Objectives: This Predictive validity, diagnostic study conduct to examine the effect of hyperbaric oxygen therapy on insulin resistance in postmenopausal women.
Official title: Effect of Hyperbaric Oxygen Therapy on Insulin Resistance in Postmenopausal Women
Key Details
Gender
FEMALE
Age Range
55 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-01-28
Completion Date
2025-04-28
Last Updated
2025-02-04
Healthy Volunteers
No
Conditions
Interventions
Hyperbaric oxygen therapy
Hyperbaric Oxygen Therapy (HBOT):(Haux, Starmed 2300, Germany). A multichamper Double-lock, divided into Main chamber and Antichamber, with omega Ω-shape and all safety and CE-Certificate,
Hypoglycemic Drug
Metformin reduces serum glucose level by several different mechanisms without increasing insulin secretion.it increases the effects of insulin so it is termed "insulin sensitizer ,metformin also suppresses the endogenous glucose production by the liver ,which is mainly due to a reduction in the rate of gluconeogenesis and asmall effect on glycogenolysis. Moreover, metformin activates the enzyme adenosine monophosphate kinase (AMPK) resulting in the inhibition of key enzymes involved in gluconeogenesis and glycogen synthesis in the liver while stimulating insulin signaling and glucose transport in muscles
Locations (1)
Kobry el koba military complex
Cairo, Cairo Governorate, Egypt