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Sufentanil in Patients With Lower Extremity Fracture Surgery Myocardial Damage Function Study
Sponsor: Second Hospital of Shanxi Medical University
Summary
1. To analyze the association of different doses of opioids on myocardial injury/protection through BMP-6/SMAD pathway. 2. To observe the effect of different doses of opioids on the expression of BMP-6 in bone marrow. 3. To investigate the relationship between different doses of opioids and BMP-6 and perioperative cardiovascular adverse events in patients with lower extremity fracture surgery.
Official title: Sufentanil is Paired Via the BMP6/SMAD Pathway Cardiac Injury in Lower Extremity Fracture Surgery Function Study
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2025-02-05
Completion Date
2025-05-10
Last Updated
2025-02-05
Healthy Volunteers
Yes
Conditions
Interventions
Sufentanil injection
Different concentrations of sufentanil were administered to three different subgroups of patients in the same way
Placebo
Placebo
Locations (1)
Second Hospital of Shanxi Medical University
Taiyuan, Shanxi, China