Clinical Research Directory

Association of EEG Parameters with Postoperative Delirium in Patient's with Parkinson's Disease

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Summary

Patients with Parkinson's disease seem prone to developing postoperative delirium after surgery, the causes of which remain understudied and multifactorial. Anesthetic management remains challenging due to the changes in neurotransmitter levels in these patients which translate to altered drug effects. Avoiding excessive anesthesia is essential. Processed electroencephalography (EEG) is used worldwide along with our centre to monitor depth of anesthesia. It is non-invasive and easy to use. Some EEG patterns like "burst suppression" are easily identifiable and indicate that the brain has fallen into an excessively low metabolic state, which could mean increased anesthetic sensitivity. Appearance of "burst suppression" can predict delirium in non-neurosurgical procedures, but this has never been studied during surgery for deep brain stimulator insertion in Parkinson's disease patients. Through this study we wish to observe the association of EEG parameters with the development of postoperative delirium in this subset of the population.This has the capacity to change anesthetic practice by being mindful of the fragile brain of such patients and individualizing drug dosing for each patient to improve outcomes and reduce hospital stay.

Official title: Association of Processed Electroencephalography Derived Parameters with Postoperative Delirium in Patients with Parkinson's Disease Undergoing Elective Neurosurgery

Key Details

Conditions

Interventions