Role of Transposable Elements in Septic Immune Aging

RECRUITING

NCT06809868

Sponsor: University of California, San Francisco

Summary

The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1. Do transposable elements prematurely age the immune systems of patients with sepsis? 2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU? 3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU? Participants will have blood drawn from them but will not be subjected to additional interventions.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

116

Start Date

2025-02-14

Completion Date

2028-08-14

Last Updated

2026-01-30

Healthy Volunteers

Yes

Conditions

Sepsis Sepsis and Septic Shock Sepsis With Multiple Organ Dysfunction (MOD)Sepsis With Acute Organ Dysfunction Sepsis, Severe Sepsis at Intensive Care Unit Sepsis, Severe Sepsis and Septic Shock Sepsis, Septic Shock

Interventions

GENETIC

RNA and DNA Sequencing

DNA and RNA sequencing will be conducted on both control participants and patients with sepsis who are admitted to the ICU.

Locations (1)

University of California, San Francisco

San Francisco, California, United States

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