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Multi-strain Probiotics to Prevent Necrotizing Enterocolitis in Very Preterm Infants
Sponsor: University of Calgary
Summary
The goal of this clinical trial is to evaluate whether multi-strain probiotics of lactobacillus and bifidobacterium can prevent necrotizing enterocolitis (NEC) in preterm infants born at less than 32 weeks of gestation. The main questions it aims to answer are: * Does the use of a multi-strain probiotic combination reduce the incidence of NEC in preterm infants? * Are there any adverse effects associated with the administration of this probiotic combination?
Official title: Multi-strain Probiotics to Prevent Necrotizing Enterocolitis in Very Preterm Infants: a Stepped-Wedge Cluster Randomized Trial
Key Details
Gender
All
Age Range
0 Hours - 72 Hours
Study Type
INTERVENTIONAL
Enrollment
2170
Start Date
2025-06-01
Completion Date
2028-05-30
Last Updated
2025-02-05
Healthy Volunteers
No
Conditions
Interventions
Multi-strain probiotics
Infants will be started on probiotics (Bifidobacterium and Lacticaseibacillus) with enetral feed.
Locations (4)
Foothills Medical Center
Calgary, Alberta, Canada
Royal Alexandra Hospital
Edmonton, Alberta, Canada
Children's and Women's health of Britch Columbia
Vancouver, British Columbia, Canada
IWK
Halifax, Canada