Clinical Research Directory
Browse clinical research sites, groups, and studies.
Polyphenol Metabotypes in People With Diabetes Type 2
Sponsor: University Hospital, Ghent
Summary
This cross-sectional study seeks to characterize the overall polyphenol metabotype in patients with T2DM in comparison to age-matched individuals without diabetes. Additionally, the study aims to identify factors that influence the polyphenol metabotype (transit time and gut microbial capacity to degrade polyphenols in particular).
Key Details
Gender
All
Age Range
40 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2026-03-04
Completion Date
2028-12
Last Updated
2026-03-23
Healthy Volunteers
Yes
Conditions
Interventions
Oral Polyphenol Challenge Test / PPPIL
Patients will receive a so-called oral polyphenol challenge test. It is a pill containing a multitude of polyphenol classes (doi: 10.1093/cdn/nzac072.020)
fasting blood sample
Fasting blood sample will be obtained for determination of markers of metabolic health.
Fasting urine collection
Subjects collect morning urine (or the urine thereafter ) in a separate urine container and write down the time of urine collection for determination of polyphenol metabolites
24 hours urine collection
Subjects collect urine over the entire 24h. for determination of polyphenol metabolites
Questionnaires
Questionnaires will be performed to collect information on lifestyle and baseline characteristics: physical activity (IPAQ), sleep (PSQI), drinking and smoking behaviour, drug intake and medical record.
Stool collection
Optional: some subjects collect stool samples to test the capacity of the microbiome to degrade polyphenols with a batch experiment.
Transit time determination
Subjects take a pill containing 90mg of royal blue dye (E133) together with the polyphenol pill to determine their transit time. When their stool discolours, the subjects notify the researcher.
Locations (2)
Ghent University
Ghent, East Flanders, Belgium
Department of rehabilitation sciences - UGent
Ghent, Belgium