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Pharmacogenetics of Response to Sitagliptin (PRS)
Sponsor: University of Maryland, Baltimore
Summary
This is a research study to find out how different people respond to a medication called sitagliptin. Sitagliptin is an FDA approved medication that is used to treat diabetes. We are asking for healthy, non-diabetic volunteers to participate in this 7-week study. If you agree to participate, you will take part in 2 clinic visits that are 4-6 weeks apart. At the clinic visits you will have an oral glucose tolerance test (OGTT) and other blood tests to see how your body processes glucose (sugar). An OGTT is a test in which your drink glucose and then blood samples are taken afterward at specific time points to measure glucose and insulin in your blood. Each clinic visit will last about 5 hours.
Official title: Sitagliptin's Effects on Glucose-stimulated Insulin Secretion and Oral Glucose
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2026-12
Completion Date
2032-12
Last Updated
2026-02-18
Healthy Volunteers
Yes
Conditions
Interventions
Oral Glucose Tolerance Test
Three hour glucose tolerance test
Locations (1)
University of Maryland Amish Research Clinic
Lancaster, Pennsylvania, United States