Clinical Research Directory

Inclusion Criteria: Subjects must meet ALL of the following criteria: General Inclusion Criteria * Age ≥18 years * Severe Mitral Regurgitation (3+ to 4+) * Symptom status: NYHA functional class ≥ II * Subjects scheduled to receive the M-TEER per the current approved indications for use * Subjects agreed to join the study and complete follow-up Exclusion Criteria: Potential Subjects will be excluded if ANY of the following criteria apply: General Exclusion Criteria * Contraindication to MRI * CABG, PCI, TAVR, CRT or CRT-D within the prior 30 days * Aortic or tricuspid valve disease requiring surgery or transcatheter intervention * COPD requiring continuous home oxygen therapy or chronic outpatient oral steroid use * Cerebrovascular accident within prior 30 days * Severe symptomatic carotid stenosis (\>70% by ultrasound) * Carotid surgery or stenting within prior 30 days * Hemodynamic instability requiring inotropic support or mechanical heart assistance * Need for emergent or urgent surgery for any reason or any planned cardiac surgery within the next 12 months. * Contraindication for transesophageal echocardiography * Life expectancy \< 1 year * Pregnant or planning pregnancy within next 12 months * Participation in another interventional Trial * Patients who are not able to give consent or complete the follow-up