Clinical Research Directory

Inclusion Criteria: * • Age \> 18, \< 90 years * Non-intubated critically ill patients with AHRF due to pneumonia (diagnosis is based on the presence of infiltrates on chest X-ray and the onset of clinical signs of infection less than 7 days earlier) * PaO2/FiO2 ≤ 300 mmHg * Patients receiving oxygen therapy Exclusion Criteria: * • Age \< 18 years * Hypercapnia (PaCO2 \> 50 mmHg) * Hemodynamic instability (Systolic blood pressure \< 90 mmHg or Mean arterial pressure \< 60 or high dose of vasoactive drugs) * Tachycardia or tachyarrhythmia (HR \> 130 b/min) * Known allergy or intolerance to salbutamol * Patient has received inhaled therapy with short-acting beta 2 agonists \< 8 hours before or with long-acting beta 2 agonists \< 24 hours before * Acute exacerbation of COPD or bronchial asthma * Cardiogenic pulmonary edema * GCS ≤ 12 * Contraindication for EIT (e.g. ICD) * Pregnancy * Patient refuses to participate