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Stress Dynamics and Familial Risk for Depression in Female Adolescents
Sponsor: Mclean Hospital
Summary
Stress and a parental history of major depressive disorder (MDD) are among the strongest risk factors for future development of MDD. Studies have shown that having a parental history of MDD may be associated with behavioral, psychophysiological, and hormonal responses to stress that are associated with poorer stress coping. . Adolescence is a vulnerable developmental window linked to increased MDD risk, especially for females, as rates of MDD surge relative to males. Despite the central role of stress in MDD onset, little is known about the brain mechanisms underlying stress responses in susceptible female adolescents at high familial risk for MDD. Also, it is unclear how stress-related brain network alterations may relate to "real-world" maladaptive stress responses and whether these stress-related brain network changes are predictive of future depression onset. We will fulfill these research gaps by combining neuroimaging with intensive longitudinal tracking of depressive symptomology as well as behavioral and physiological responses to "real world" stress using smartphone and smartwatch technology. Elucidating these neural mechanisms may aid in the discovery of MDD biomarkers that could identify youth at greatest risk for future MDD development and lead to earlier intervention efforts.
Official title: Tracking the Dynamic Trajectory of Behavioral, Physiological, and Neurobiological Stress Responses in Female Adolescents at High and Low Familial Risk for Depression
Key Details
Gender
FEMALE
Age Range
13 Years - 15 Years
Study Type
INTERVENTIONAL
Enrollment
148
Start Date
2025-10-15
Completion Date
2030-03-31
Last Updated
2025-10-23
Healthy Volunteers
Yes
Conditions
Interventions
Computer Task Manipulation
Participants will complete computer tasks.
Locations (1)
McLean Hospital
Belmont, Massachusetts, United States