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The Effects of Iron Treatment on Malaria and Measles Vaccine Response in Kenyan Infants With Iron Deficiency
Sponsor: Nicole Stoffel
Summary
Malaria and iron deficiency cause a significant burden of disease in Africa. Iron deficiency (ID) might affect immune responses to vaccination. In this double-blind randomized controlled trial, we aim to assess: (1) whether ID impairs R21/Matrix-M and measles (MR) vaccine response, (2) whether iron treatment at time of vaccination improves vaccine response.
Key Details
Gender
All
Age Range
6 Months - 6 Months
Study Type
INTERVENTIONAL
Enrollment
324
Start Date
2026-01-05
Completion Date
2028-04-30
Last Updated
2025-12-26
Healthy Volunteers
No
Conditions
Interventions
Iron syrup
Iron syrup administered daily from 6 to 10 months of age.
Multivitamin syrup
Multivitamin syrup administered daily from 6 to 10 months of age.
R21-Matrix/M Vaccine (malaria vaccine)
R21-Matrix/M vaccine administered in 3 doses at 7, 8 and 9 months of age.
Measles-Rubella vaccine
Measles-Rubella vaccine administered at 9 months of age.