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Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials
Sponsor: Jian-Xin Zhou
Summary
Spontaneous breathing trials (SBT) are essential for assessing extubation tolerance, yet optimal approaches are debated. High-flow nasal oxygen offers benefits like precise oxygen delivery, flow-related positive end-expiratory pressure generation and improved lung function. While high-flow tracheal oxygen can also be used as an SBT method, it has reduced physiological effects due to bypassing the upper airway with a more open circuit. To enhance this limitation, investigators developed a modified high-flow tracheal oxygen tube with a smaller expiratory end diameter to increase expiratory resistance and airway pressure. This is a prospective randomized crossover study that aims to compare the physiological effects of standard and modified high-flow tracheal oxygen versus T-piece during SBT.
Official title: Comparison of Physiological Effects of Two Types of High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials in Mechanically Ventilated Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-03-01
Completion Date
2025-12-30
Last Updated
2025-03-21
Healthy Volunteers
No
Interventions
Modified high flow tracheal oxygen-40L/min
Modified high-flow tracheal oxygen with a flow rate of 40L/min will be performed.
Standard high flow tracheal oxygen-40L/min
Standard high-flow tracheal oxygen with a flow rate of 40 L/min will be performed.
T-piece
T-piece will be performed.
Modified high-flow tracheal oxygen-60L/min
Modified high-flow tracheal oxygen with a flow rate of 60L/min will be performed.
Standard high-flow tracheal oxygen-60 L/min
Standard high-flow tracheal oxygen with a flow rate of 60 L/min will be performed.
Locations (1)
Beijing Shijitan Hospital
Beijing, Beijing Municipality, China