Clinical Research Directory

Inclusion Criteria: * Male or female 19 years of age and older * Unilateral shoulder pain with a pain score of 4 or higher. * patients with a symptom duration of at least three months who have not responded to conventional treatments, including analgesics. * patients diagnosed with massive or extensive full-thickness rotator cuff tears confirmed by computed tomography arthrography or magnetic resonance imaging. Exclusion Criteria: * patients diagnosed with small or medium full-thickness rotator cuff tears among study participants with full-thickness rotator cuff tears. * patients who have received subacromial injection therapy in the affected shoulder within the past three months. * patients who have undergone rotator cuff surgery on the affected shoulder within the past six months. * patients exhibiting or suspected of having the following radiological findings: malignant tumors, severe glenohumeral osteoarthritis, or bony abnormalities causing subacromial space narrowing. * patients presenting with symptomatic cervical spine disorders. * patients experiencing bilateral shoulder pain. * patients diagnosed with multiple arthritis, infectious arthritis, rheumatoid arthritis, or fibromyalgia. * patients with neurological deficits. * Pregnant or breastfeeding patients * patients unwilling to use effective contraception during the study period. * patients currently infected with HBV, HCV, or HIV, or those with a positive RPR test result. * patients with severe conditions that may affect the study, including cardiovascular diseases, renal diseases, hepatic diseases, endocrine disorders, or malignancies. * patients who are unable to comprehend the questionnaires used for study assessments, including the Visual Analog Scale (VAS), or those with communication difficulties due to psychiatric disorders. * Any other cases deemed inappropriate for study participation by the investigator.