Clinical Research Directory

Inclusion Criteria: * Severe symptomatic AS reviewed and accepted for Transfemoral (TF) TAVI by an established Heart Team * Obtained informed consent Exclusion Criteria: * Ambiguous aortic annular sizing on CT measurement deemed to increase the risk of valve embolization * Hostile aortic root on CT for TAVI implantation defined by, but not limited to: * High risk LVOT with a dimension significantly smaller than the annulus and/or extensive calcification * Features that increase the risk of coronary artery occlusion including inadequate coronary artery height and/or shallow coronary sinuses in the setting of a significant coronary artery territory at risk (accounting for prior CABG) * High risk STJ anatomy defined by inadequate height and/or diameter and/or excessive calcification * Vascular anatomy with increased risk of ascending aorta trauma (i.e. combinations of existing ascending aortic aneurysm, and/or unfolded aorta and/or extensive tortuosity and/or excessive iliofemoral calcification) * GFR \<15, excluding patients on dialysis * Life expectancy less than 3 years * Any factor precluding 1-year follow-up