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A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)
Sponsor: Merck Sharp & Dohme LLC
Summary
Researchers are looking for new ways to treat people with certain advanced solid tumors. Advanced means the cancer has spread to other parts of the body and cannot be removed with surgery. Solid tumors are cancers mostly in body organs and tissues, not in the blood or other body liquids. The main goal of this study is to learn about the safety of MK-3120 and if people tolerate it.
Official title: A Phase 1/2 Open-label Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
270
Start Date
2025-03-25
Completion Date
2031-03-25
Last Updated
2026-02-19
Healthy Volunteers
No
Conditions
Interventions
MK-3120
IV infusion
Locations (42)
The University of Alabama at Birmingham ( Site 1005)
Birmingham, Alabama, United States
University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 1003)
Miami, Florida, United States
John Theurer Cancer Center at Hackensack University Medical Center ( Site 1009)
Hackensack, New Jersey, United States
Virginia Commonwealth University ( Site 1008)
Richmond, Virginia, United States
Centro de Estudios Clínicos SAGA ( Site 0033)
Santiago, Region M. de Santiago, Chile
FALP ( Site 0031)
Santiago, Region M. de Santiago, Chile
Pontificia Universidad Catolica de Chile ( Site 0032)
Santiago, Region M. de Santiago, Chile
Bradford Hill Centro de Investigaciones Clinicas ( Site 0030)
Santiago, Region M. de Santiago, Chile
Peking University First Hospital ( Site 0180)
Beijing, Beijing Municipality, China
Chongqing Cancer Hospital ( Site 0186)
Chongqing, Chongqing Municipality, China
Hunan Cancer Hospital ( Site 0181)
Changsha, Hunan, China
The First Hospital of Jilin University ( Site 0185)
Changchun, Jilin, China
West China Hospital Sichuan University ( Site 0187)
Chengdu, Sichuan, China
Institut Paoli Calmettes ( Site 0053)
Marseille, Bouches-du-Rhone, France
Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer-Medical Oncology ( Site 0054)
Rennes, Ille-et-Vilaine, France
Centre Oscar Lambret ( Site 0051)
Lille, Nord, France
Gustave Roussy ( Site 0050)
Villejuif, Val-de-Marne, France
Rambam Health Care Campus ( Site 0082)
Haifa, Israel
Rabin Medical Center ( Site 0081)
Petah Tikva, Israel
Sheba Medical Center ( Site 0080)
Ramat Gan, Israel
National Cancer Center Hospital East ( Site 0190)
Kashiwa, Chiba, Japan
Cancer Institute Hospital of JFCR ( Site 0192)
Koto, Tokyo, Japan
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 0191)
Osaka, Japan
Radboudumc ( Site 0091)
Nijmegen, Gelderland, Netherlands
Nederlands Kanker Instituut - Antoni van Leeuwenhoek - NKI-AVL ( Site 0090)
Amsterdam, North Holland, Netherlands
Amsterdam UMC, locatie VUmc ( Site 0093)
Amsterdam, North Holland, Netherlands
Erasmus Medisch Centrum ( Site 0092)
Rotterdam, South Holland, Netherlands
Seoul National University Hospital ( Site 0150)
Seoul, South Korea
Severance Hospital Yonsei University Health System ( Site 0151)
Seoul, South Korea
Asan Medical Center ( Site 0153)
Seoul, South Korea
Samsung Medical Center ( Site 0152)
Seoul, South Korea
Institut Català d'Oncologia - L'Hospitalet ( Site 0113)
L'Hospitalet de Llobregat, Barcelona, Spain
HOSPITAL CLÍNIC DE BARCELONA ( Site 0112)
Barcelona, Catalonia, Spain
Hospital Universitario Fundación Jiménez Díaz-START Madrid-FJD ( Site 0111)
Madrid, Madrid, Comunidad de, Spain
Hospital Universitario Virgen de la Victoria ( Site 0114)
Málaga, Spain
Chi Mei Medical Center ( Site 0162)
Tainan, Tainan, Taiwan
National Cheng Kung University Hospital ( Site 0161)
Tainan, Taiwan
National Taiwan University Hospital ( Site 0160)
Taipei, Taiwan
Ankara Bilkent Şehir Hastanesi. ( Site 0131)
Çankaya, Ankara, Turkey (Türkiye)
Ankara University Health Practice and Research Hospitals ( Site 0134)
Ankara, Turkey (Türkiye)
Hacettepe Universite Hastaneleri ( Site 0130)
Ankara, Turkey (Türkiye)
Koc University, School of Medicine ( Site 0133)
Istanbul, Turkey (Türkiye)