Clinical Research Directory

Inclusion Criteria: * presence of mild (one or two neuropsychological tests below the cut-off score, 5th percentile) or severe (more than two neuropsychological tests below the cut-off score, 5th percentile) cognitive impairment, * mild to moderate walking disability with Expanded Disability Status Scale (EDSS) between 3 and 6, * no relapse or associated steroid use in the past three months, * adequate visual and auditory capacity to operate computer software. Exclusion Criteria: * presence of other neurological disorders than MS, * major psychiatric disorders, * high levels of anxiety and/or depression (score\>20 for Depression scale and up to 14 for Anxiety scale on Italian adaptation of the Depression, Anxiety and Stress Scale (DASS-21), * substance abuse, * any type of rehabilitation intervention in the month prior to recruitment * pharmacological therapy not well defined and/or changed during the study * presence of paroxysmal vertigo * lower limb botulinum toxin injections within the previous 12 weeks