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Pilot Study to Characterize the Endometriosis Steroidome and Its Link to Endocrine Disruptors and Vaginal Dysbiosis
Sponsor: Nantes University Hospital
Summary
Endometriosis is a systemic, steroid-dependent, inflammatory disease characterized by the growth of endometrial-like tissue outside the uterus, affecting approximately 10 % of women of childbearing age. The etiology and pathophysiology of endometriosis is not completely understood to support effective treatment and prevention strategies. Despite the steroid dependency, little is known concerning the underlying metabolism of estrogen and other tightly related steroids. Moreover, shortening the long diagnostic delays is a major priority in endometriosis research.
Official title: STERONLINE: Steroidome and Exposome of Endometriosis Single-center Case-control Study
Key Details
Gender
FEMALE
Age Range
18 Years - 45 Years
Study Type
OBSERVATIONAL
Enrollment
135
Start Date
2025-07-15
Completion Date
2027-03-15
Last Updated
2025-05-29
Healthy Volunteers
No
Conditions
Interventions
Blood test
A blood test (2 x 5 ml dry tubes) will be taken to analyze steroid profiles
urine sample
a 20 ml urine sample will be taken to analyze steroid profiles
vaginal sample
to characterize the microbiota.