Inclusion Criteria:
1. Written informed consent obtained from the participant.
2. Be male or female between the ages of:
1. ≥ 18 and ≤ 55 years for phase I
2. ≥ 18 and ≤ 60 years for phase II.
3. Good general health as determined at the discretion of the investigator (vital signs, medical history, and physical examination).
4. BMI: 18,5 kg/m² ≤ BMI ˂30 kg/m².
5. Received at least 3 doses of a COVID-19 mRNA vaccine, last booster dose received at least 6 months prior to trial vaccine administration OR 2 doses of a COVID-19 mRNA vaccine and confirmed SARS-CoV-2 infection at least 6 months prior to inclusion in the trial.
6. Has expressed interest and availability to meet the trial requirements.
7. For a woman of childbearing potential, plan to be non-pregnant AND use of highly effective contraception from screening until the end of the trial.
8. Agree to abstain from donating blood/plasma or any other bodily fluids from the time of vaccination until 1 year after vaccination (only for LVT-001 vaccine).
9. Agree to stay in the geographical area of one of the clinical sites for the duration of the trial.
10. Agree to implement barrier measures as much as possible (washing hands and wearing a mask) against COVID-19 and respiratory infections between D0 and D28.
11. Agree to be registered in the computerized file of the Ministry of Health (VRB).
12. Be affiliated to French social security system.
Exclusion Criteria:
1. Temperature ≥ 38.0°C or symptoms of acute self-limiting illness such as upper respiratory tract infection or gastroenteritis within three days prior to vaccine dose.
2. Any form of contraindication to the trial vaccines tested.
3. History of chronic rhinitis, nasal septal defect, cleft palate, nasal polyps, or other nasal abnormality that might alter nasal mucosa and affect vaccine response.
4. A piercing or obstruction in the nostrils that could impede vaccine administration.
5. Previous nasal surgery or nasal cauterization.
6. History of frequent epistaxis.
7. Virologically documented (PCR or antigenic test) history of COVID-19 in the past 6 months.
8. Positive COVID-19 PCR test at screening visit.
9. Medical problems due to alcohol.
10. Illicit drug use within the past 12 months.
11. Participation in another trial within 60 days prior to the enrolment visit or planned participation during the present trial period in another clinical study investigating a vaccine, drug, medical device, or medical procedure.
Note: Participation in an observational study is allowed.
12. Received influenza vaccination within 14 days prior to trial vaccination, or any other licensed vaccine within 4 weeks prior to study vaccination.
13. Vaccination with a COVID-19 vaccine other than mRNA vaccine.
14. Known sensitivity to any of the ingredients of the trial vaccines.
15. Known allergic reaction to plastic.
16. Positive serology for hepatitis B (HBsAg), C (anti-HCV antibodies) and HIV 1-2.
17. History of severe adverse events following vaccine administration including anaphylactic reaction and associated symptoms such as rash, breathing problems, angioedema, and abdominal pain, or a history of allergic reaction that could be triggered by a component of the SARS-CoV-2 vaccine at the time of the first vaccine administration.
18. Pregnancy positive test (βHCG test) or pregnancy or breastfeeding.
19. Received immunoglobulin or other blood products within three months prior to inclusion or planned administration before the trial completion.
20. Received an immunosuppressive therapy for underlying disease or a treatment with immunosuppressive or cytotoxic drugs or a cancer chemotherapy or radiation therapy within the previous 36 months.
21. Received drugs such as corticosteroids at a dosage \> 10 mg prednisone equivalent/day or inhalers corticosteroids, within 3 months prior to inclusion (excluding corticosteroid topical preparations for cutaneous application).
22. Abnormal and deemed clinically significant result by the investigator following the routine analyzes carried out at the time of the screening visit (any grade 4 biological result, even if deemed not clinically significant by the investigator, constitutes an exclusion criterion).
23. History of severe psychiatric disorders that may affect participation in the trial.
24. Any other serious chronic illness requiring immediate monitoring by a hospital specialist.
25. Any other condition that, in the opinion of the investigator, would compromise the safety or rights of a volunteer participating in the trial or render the subject unable to comply with the protocol.
26. Phase II only: Participants included in phase I will not be included in phase II.
27. Participants under legal protection (e.g., guardianship, tutorship).
