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Investigating the Brain's Physiological Responses in Depression and Autism, Using Transcranial Magnetic Stimulation and Electroencephalography
Sponsor: National Taiwan University Hospital
Summary
The goal of this observational study is to investigate the brain physiological responses in depression and autism. The main questions aim to answer are: 1. Comparing the ratios of cortical excitation and inhibition among four groups: autism group, autism with depression group, depression group, and normal control group using Transcranial magnetic stimulation and electroencephalography (TMS-EEG). This study explores the relationship between the ratios of cortical excitation and inhibition and the severity of clinical symptoms. 2. Comparing the brain inflammation among four groups: autism group, autism with depression group, depression group, and normal control group using Positron emission tomography (PET). This study investigates the relationship between brain inflammation and the severity of clinical symptoms. 3. The mutual influence between the severity of brain inflammation and Excitatory/inhibitory imbalance (E/I imbalance). Participants will receive clinical assessment, neurocognitive function tests, TMS-EEG, gamma oscillation, and PET examinations.
Official title: Social Cognition in Major Depression and Autism Spectrum Disorder: Cortical Excitatory-inhibitory Imbalance and Neuromechanism
Key Details
Gender
All
Age Range
20 Years - 50 Years
Study Type
OBSERVATIONAL
Enrollment
160
Start Date
2024-05-28
Completion Date
2026-12-31
Last Updated
2026-01-12
Healthy Volunteers
Yes
Conditions
Interventions
Positron Emission Tomography (PET)
18F-N-((2-(2-(fluoro-18f)ethoxy)phenyl)methyl)-N-(4-phenoxy-3-pyridinyl) acetamide
transcranial magnetic stimulation and electroencephalography(TMS-EEG)
single pulse and paired pulse
Locations (1)
National Taiwan University Hospital
Taipei, Taiwan