Clinical Research Directory

Inclusion criteria for patients included in the CELLCORDES 2 clinical trial * Voice Handicap Index \> 50/120 * Scarring, congenital (sulcus) or post-phonosurgery vocal cords * Vibratory anomalies in the middle third of one or both vocal cords on stroboscopy * A minimum of six months after the initial surgery * Patients aged 18 to 70 years * Good general health * Negative pregnancy test and contraception for women of childbearing age Signature of consent for the storage and use of biological samples Inclusion criteria for Healthy donnors: * Liposuction surgery for aesthetic reasons * BMI between 18 and 27 * No chronic diseases * Non-opposition to the use of surgical waste for research purposes after freezing in a biological collection Exclusion criteria: For all patients: * Refusal or inability to comply with the study procedures * Minors * Pregnant or breastfeeding women * Legally protected adults (under guardianship or curatorship) * Individuals residing in a healthcare or social establishment emergency situations * Individuals deprived of liberty * Detainees * Individuals not covered by a social security scheme * Use of an experimental drug in the last three months * Contraindication to local anesthesia * Anticoagulant treatment * Coagulation disorders (TP \< 65%, TCA \> 1.2) * Premenopausal women of childbearing age without contraception * Lack of or refusal of informed consent Exclusion criteria for Patients in the CELLCORDES 2 clinical trial: * Patients refusing pre- and post-operative speech therapy * History of malignant lesions or severe dysplasia on the scarred vocal cord * History of laryngeal papillomatosis * Active infectious diseases * Positive serology for HIV1 and 2, p24 Ag, HCV Abs, HBs Ag, HbC Abs, HTLV and II Abs, TPHA * Need for perioperative antibiotic prophylaxi