Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)
Sponsor: Merck Sharp & Dohme LLC
Summary
The main goals of this study are to learn about the safety of sacituzumab tirumotecan with bevacizumab and if people tolerate it; and if people who take sacituzumab tirumotecan with or without bevacizumab live longer without the cancer getting worse than those who receive standard of care treatment.
Official title: A Phase 3, Randomized, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan Maintenance Treatment With or Without Bevacizumab Versus Standard of Care After Second-line Platinum-based Doublet Chemotherapy in Participants With Platinum-sensitive Recurrent Ovarian Cancer (TroFuse-022/ENGOT-ov84/GOG-3103)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
770
Start Date
2025-04-09
Completion Date
2032-11-09
Last Updated
2026-04-02
Healthy Volunteers
No
Interventions
Sacituzumab tirumotecan
IV Infusion
Bevacizumab
IV Infusion
H1 receptor antagonist
Rescue medication taken per approved product label before sacituzumab tirumotecan
H2 receptor antagonist
Rescue medication taken per approved product label before sacituzumab tirumotecan
Acetaminophen (or equivalent)
Rescue medication taken per approved product label before sacituzumab tirumotecan
Dexamethasone (or equivalent)
Rescue medication taken per approved product label before sacituzumab tirumotecan
Steroid mouthwash (dexamethasone or equivalent)
Rescue medication taken orally 2-4 times daily
Locations (152)
University of Alabama at Birmingham ( Site 0006)
Birmingham, Alabama, United States
Alaska Women's Cancer Care ( Site 0096)
Anchorage, Alaska, United States
Yale-New Haven Hospital-Smilow Cancer Hospital at Yale-New Haven ( Site 0001)
New Haven, Connecticut, United States
Mount Sinai Cancer Center ( Site 0078)
Miami Beach, Florida, United States
Sarasota Memorial Hospital ( Site 0075)
Sarasota, Florida, United States
Florida Cancer Specialists East ( Site 7000)
West Palm Beach, Florida, United States
Winship Cancer Institute of Emory University ( Site 0086)
Atlanta, Georgia, United States
Augusta University - Georgia Cancer Center ( Site 0066)
Augusta, Georgia, United States
Parkview Research Center at Parkview Regional Medical Center ( Site 0003)
Fort Wayne, Indiana, United States
Women's Cancer Care ( Site 0067)
Covington, Louisiana, United States
Maine Medical Center Research Institute-MaineHealth/Maine Medical Partners - GynOnc ( Site 0008)
Scarborough, Maine, United States
St. Dominic's Hospital ( Site 0064)
Jackson, Mississippi, United States
Nebraska Methodist Hospital ( Site 0053)
Omaha, Nebraska, United States
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0081)
Hackensack, New Jersey, United States
Rutgers Cancer Institute of New Jersey ( Site 0071)
New Brunswick, New Jersey, United States
University of New Mexico Comprehensive Cancer Center ( Site 0055)
Albuquerque, New Mexico, United States
NYU Langone Hospital - Long Island ( Site 0015)
Mineola, New York, United States
Laura and Isaac Perlmutter Cancer Center ( Site 0076)
New York, New York, United States
FirstHealth Cancer Center ( Site 0079)
Pinehurst, North Carolina, United States
University of Cincinnati Medical Center ( Site 0090)
Cincinnati, Ohio, United States
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0056)
Tulsa, Oklahoma, United States
Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8010)
Eugene, Oregon, United States
Women & Infants Hospital ( Site 0050)
Providence, Rhode Island, United States
Texas Oncology - Central/South Texas ( Site 8009)
Austin, Texas, United States
Texas Oncology - DFW ( Site 8001)
Fort Worth, Texas, United States
Texas Oncology - San Antonio ( Site 8005)
San Antonio, Texas, United States
Texas Oncology - Gulf Coast ( Site 8003)
Webster, Texas, United States
Virginia Cancer Specialists (VCS) ( Site 8011)
Fairfax, Virginia, United States
Instituto Alexander Fleming ( Site 2909)
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Instituto de Investigaciones Clinicas Mar del Plata ( Site 2901)
Mar del Plata, Buenos Aires, Argentina
Fundación Respirar ( Site 2912)
Buenos Aires, Buenos Aires F.D., Argentina
Instituto de Oncologia de Rosario ( Site 2910)
Rosario, Santa Fe Province, Argentina
Hospital Aleman ( Site 2903)
CABA, Argentina
Hospital Italiano de Cordoba ( Site 2908)
Córdoba, Argentina
Blacktown Hospital ( Site 0211)
Sydney, New South Wales, Australia
Gallipoli Medical Research Ltd ( Site 0214)
Brisbane, Queensland, Australia
Epworth Freemasons ( Site 0217)
East Melbourne, Victoria, Australia
Frankston Hospital ( Site 0216)
Frankston, Victoria, Australia
Antwerp University Hospital ( Site 0304)
Edegem, Antwerpen, Belgium
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman ( Site 0306)
Liège, Liege, Belgium
CHU UCL Namur/Site Sainte Elisabeth ( Site 0302)
Ghent, Oost-Vlaanderen, Belgium
UZ Leuven ( Site 0301)
Leuven, Vlaams-Brabant, Belgium
Liga Norte Riograndense Contra o Cancer ( Site 0423)
Natal, Rio Grande do Norte, Brazil
ANIMI - Unidade de Tratamento Oncologico ( Site 0419)
Lages, Santa Catarina, Brazil
Hospital Paulistano ( Site 0421)
São Paulo, Brazil
IBCC - Núcleo de Pesquisa e Ensino ( Site 0424)
São Paulo, Brazil
Princess Margaret Cancer Centre ( Site 0518)
Toronto, Ontario, Canada
McGill University Health Centre ( Site 0502)
Montreal, Quebec, Canada
Clinica Puerto Montt ( Site 0615)
Port Montt, Los Lagos Region, Chile
ONCOCENTRO APYS-ACEREY ( Site 0612)
Viña del Mar, Región de Valparaíso, Chile
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0806)
Bogotá, Bogota D.C., Colombia
Instituto Nacional De Cancerologia ( Site 0807)
Bogotá, Bogota D.C., Colombia
Oncologos Del Occidente ( Site 0805)
Pereira, Risaralda Department, Colombia
Fakultni nemocnice Ostrava ( Site 3323)
Ostrava-Poruba, Ostrava Mesto, Czechia
Vseobecna fakultni nemocnice v Praze ( Site 3325)
Prague, Czechia
Herlev Hospital ( Site 0903)
Herlev, Capital Region, Denmark
Aalborg Universitetshospital ( Site 0901)
Aalborg, North Denmark, Denmark
Vejle Sygehus ( Site 0902)
Vejle, Region Syddanmark, Denmark
Oulun yliopistollinen sairaala ( Site 1003)
Oulu, North Ostrobothnia, Finland
Kuopion Yliopistollinen Sairaala ( Site 1004)
Kuopio, Northern Savonia, Finland
Tampereen yliopistollinen sairaala ( Site 1002)
Tampere, Pirkanmaa, Finland
Centre Oscar Lambret ( Site 1104)
Lille, Ain, France
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 1101)
Bordeaux, Aquitaine, France
Centre Hopitalier Lyon Sud ( Site 1110)
Pierre-Bénite, Auvergne-Rhône-Alpes, France
Centre Francois Baclesse ( Site 1108)
Caen, Calvados, France
Hôpital Privé Des Côtes d'Armor ( Site 1106)
Plérin, Cotes-d Armor, France
Oncopole Claudius Regaud ( Site 1109)
Toulouse, Haute-Garonne, France
Pôle Santé Léonard de Vinci ( Site 1112)
Chambray-lès-Tours, Indre-et-Loire, France
Groupe Hospitalier Broca Cochin Hotel Dieu ( Site 1111)
Paris, Paris, France
Sainte Catherine Institut du Cancer Avignon Provence ( Site 1105)
Avignon, Vaucluse, France
Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 1102)
Paris, France
Aretaieio Hospital ( Site 0701)
Athens, Attica, Greece
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Onkoterapias Klinika ( Site 3924)
Szeged, Csongrád megye, Hungary
Debreceni Egyetem Klinikai Kozpont ( Site 3922)
Debrecen, Hajdú-Bihar, Hungary
Hillel Yaffe Medical Center ( Site 1404)
Hadera, Israel
Rambam Health Care Campus ( Site 1402)
Haifa, Israel
Shaare Zedek Medical Center ( Site 1405)
Jerusalem, Israel
Meir Medical Center. ( Site 1403)
Kfar Saba, Israel
CRO-IRCCS ( Site 1510)
Aviano, Friuli Venezia Giulia, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1507)
Milan, Milano, Italy
Azienda Ospedaliero Universitaria Pisana ( Site 1504)
Pisa, Tuscany, Italy
Instituto Tumori Giovanni Paolo II ( Site 1505)
Bari, Italy
Istituto Europeo di Oncologia ( Site 1506)
Milan, Italy
Humanitas San Pio X Hospital ( Site 1503)
Milan, Italy
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1501)
Naples, Italy
Istituto Oncologico Veneto IRCCS ( Site 1508)
Padova, Italy
Fondazione Policlinico Universitario Agostino Gemelli ( Site 1502)
Roma, Italy
Ospedale Mauriziano ( Site 1509)
Torino, Italy
Aichi Cancer Center ( Site 1626)
Nagoya, Aichi-ken, Japan
National Hospital Organization Shikoku Cancer Center ( Site 1631)
Matsuyama, Ehime, Japan
Ehime University Hospital ( Site 1637)
Tōon, Ehime, Japan
Kurume University Hospital ( Site 1640)
Kurume, Fukuoka, Japan
Gunma Prefectural Cancer Center ( Site 1630)
Ōta, Gunma, Japan
Hokkaido University Hospital ( Site 1634)
Sapporo, Hokkaido, Japan
Iwate Medical University Hospital ( Site 1635)
Shiwa-gun, Iwate, Japan
Saitama Medical University International Medical Center ( Site 1632)
Hidaka, Saitama, Japan
Cancer Institute Hospital of JFCR ( Site 1639)
Koto, Tokyo, Japan
Keio University Hospital ( Site 1636)
Shinjyuku, Tokyo, Japan
National Hospital Organization Kyushu Cancer Center ( Site 1628)
Fukuoka, Japan
Kagoshima City Hospital ( Site 1638)
Kagoshima, Japan
Niigata Cancer Center Hospital ( Site 1633)
Niigata, Japan
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 1629)
Osaka, Japan
CIO - Centro de Inmuno-Oncología de Occidente ( Site 1719)
Guadalajara, Jalisco, Mexico
Higiea Oncologia ( Site 1713)
Mexico City, Mexico City, Mexico
Hospital Universitario "Dr. Jose Eleuterio Gonzalez" ( Site 1711)
Monterrey, Nuevo León, Mexico
I CAN ONCOLOGY CENTER S.A. DE C.V. ( Site 1716)
Monterrey, Nuevo León, Mexico
Servicios de Oncología Médica Integral - Monterrey ( Site 1712)
Monterrey, Nuevo León, Mexico
Centro de Investigación Oncológica Galerías SC ( Site 1720)
Aguascalientes, Mexico
Cryptex Investigación Clínica S.A. de C.V. ( Site 1715)
Cuauhtémoc, Mexico
COI Centro Oncologico Internacional S.A.P.I. de C.V. ( Site 1717)
Mexico City, Mexico
Centro de Investigacion Clinica de Oaxaca ( Site 1714)
Oaxaca City, Mexico
Hospital Guillermo Almenara Irigoyen ( Site 3608)
Lima, Peru
IPOR Instituto Peruano de Oncología & Radioterapia ( Site 3604)
Lima, Peru
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 3601)
Lima, Peru
Clínica San Felipe ( Site 3603)
Lima, Peru
Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 2106)
Poznan, Greater Poland Voivodeship, Poland
Bialostockie Centrum Onkologii ( Site 2104)
Bialystok, Podlaskie Voivodeship, Poland
Swietokrzyskie Centrum Onkologii. ( Site 2105)
Kielce, Świętokrzyskie Voivodeship, Poland
Hospital da Luz ( Site 3802)
Lisbon, Portugal
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 3801)
Porto, Portugal
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2215)
Cluj-Napoca, Cluj, Romania
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2211)
Craiova, Dolj, Romania
Cabinet Medical Oncomed ( Site 2217)
Timișoara, Timiș County, Romania
Spitalul Clinic Filantropia ( Site 2213)
Bucharest, Romania
National Cancer Center ( Site 2305)
Goyang-si, Kyonggi-do, South Korea
Severance Hospital ( Site 2302)
Seodaemun-Gu, Seoul, South Korea
Asan Medical Center ( Site 2304)
Songpa-gu, Seoul, South Korea
Seoul National University Hospital ( Site 2301)
Seoul, South Korea
Samsung Medical Center ( Site 2303)
Seoul, South Korea
Institut Català d'Oncologia (ICO) - Girona ( Site 2402)
Girona, Gerona, Spain
Hospital General Gregorio Maranon de Madrid ( Site 2412)
Madrid, Madrid, Comunidad de, Spain
Clinica Universidad de Navarra ( Site 2407)
Madrid, Madrid, Comunidad de, Spain
Hosp Clinico Universitario de Valencia ( Site 2401)
Valencia, Valenciana, Comunitat, Spain
Hospital Vall D Hebron ( Site 2403)
Barcelona, Spain
Hospital Clinic I Provincial de Barcelona ( Site 2409)
Barcelona, Spain
ICO L Hospitalet ( Site 2408)
Barcelona, Spain
Hospital Universitario Reina Sofia ( Site 2406)
Córdoba, Spain
Hospital Ramon y Cajal ( Site 2405)
Madrid, Spain
Hospital Clinico San Carlos... ( Site 2410)
Madrid, Spain
Hospital Universitario 12 de Octubre ( Site 2411)
Madrid, Spain
Hospital Universitario La Paz ( Site 2404)
Madrid, Spain
Taichung Veterans General Hospital ( Site 2603)
Taichung, Taiwan
National Cheng Kung University Hospital ( Site 2602)
Tainan, Taiwan
National Taiwan University Hospital ( Site 2601)
Taipei, Taiwan
Mackay Memorial Hospital ( Site 2604)
Taipei, Taiwan
Chang Gung Memorial Hospital - Linkou Branch ( Site 2605)
Taoyuan District, Taiwan
Ramathibodi Hospital ( Site 3402)
Bangkok, Bangkok, Thailand
Faculty of Medicine Siriraj Hospital ( Site 3401)
Bangkok, Bangkok, Thailand
Western General Hospital ( Site 2806)
Edinburgh, Edinburgh, City of, United Kingdom
ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 2801)
London, London, City of, United Kingdom
Royal Marsden Hospital (Sutton) ( Site 2802)
Sutton, London, City of, United Kingdom
Leicester Royal Infirmary ( Site 2808)
Leicester, United Kingdom