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Performance of Lung MRI Combined to Synthetic CT in the Follow-up of Lung Nodules
Sponsor: University Hospital, Bordeaux
Summary
Lung cancer screening trials using low-dose chest CT scans have shown a significant reduction of cancer related mortality in subjects at high risk of lung cancer. However, high rate of false positives and overdiagnosis have led to invasive methods, which are not without risks. Evaluation of lung nodules using lung MRI with ultra short echo time sequences (UTE) has been found comparable to chest CT scans. Moreover, MRI has the advantage of multiparametric characterization of lesions using different tissue contrasts. Following the recommendation of the French National Authority for Health (HAS) to evaluate new methods of lung cancer screening, this prospective single center pilot study is designed to evaluate the performance of multiparametric lung MRI combined to synthetic CT in the diagnosis of lung cancer in heavily smokers or ex-smokers professionally exposed to carcinogens
Key Details
Gender
All
Age Range
55 Years - 74 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2025-02-12
Completion Date
2027-02
Last Updated
2025-02-19
Healthy Volunteers
No
Conditions
Interventions
multiparametric MRI
An MRI scan will be performed within 2 weeks of the discovery of a solid lung nodule ≥ 5mm on the screening scan. When a follow-up scan is indicated, an MRI will be repeated on the same day as the follow-up scan. The MRI sequences that will be performed are: SpiraleVibe UTE, T1map, T2 map and Diffusion. A synthetic scanner image will be generated from the UTE morphological MRI image using a generative artificial intelligence (GAN) model.
Locations (1)
CHU Bordeaux
Pessac, France