Clinical Research Directory

Inclusion Criteria: 1. Age ≥18 years, male or female; 2. KPS score (KPS) ≥70; 3. Esophageal squamous cell carcinoma confirmed by histopathology; 4. Clinical stage cT1b-4aN+M0,T3-4aN0M0; 5. Surgical resection was performed after 2\~4 cycles of neoadjuvant therapy. 6. Expected survival \> 6 months. Exclusion Criteria: 1. Have a history of other malignancies (except for cancer in situ that has been cured and other malignancies that have been cured for more than 5 years); 2. There are contraindications of immunotherapy or chemoradiotherapy; 3. Inability to tolerate or refuse surgery; 4. Distant metastasis has occurred;