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Hypofractionated Radiation Fractionation in Breast Cancer Patients With Implant-Based Reconstruction
Sponsor: The First Affiliated Hospital with Nanjing Medical University
Summary
It is a randomized trial to assess the safety and efficacy between hypofractionation radiation and conventional radiation in women who have undergone mastectomy and immediate breast reconstruction. The investigators will evaluate reconstruction complication, radiotherapy side effects, cosmetic and oncologic outcomes.
Key Details
Gender
FEMALE
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
840
Start Date
2025-01-30
Completion Date
2033-12
Last Updated
2025-02-17
Healthy Volunteers
No
Conditions
Interventions
Hypofractionated Radiation Therapy
Hypofractionation regimen: Total dose to the chest wall and the regional lymph nodes is 4050 cGy, and each fraction consists of 270 cGy per day(daily, Monday through Friday )
Conventional fraction radiotherapy
Total dose of plan tumor volume is 5000 cGy，and each fraction will consist of 200 cGy per day. 25 fractions(daily, Monday through Friday) to the chest wall and to the supraclavicular (with or without axillary) lymph nodes.
Locations (1)
Jiangsu Province People's Hospital/The First Affiliated with Nanjing Medical University
Nanjing, Jiangsu, China