Clinical Research Directory

Inclusion Criteria: * 18-80 years of age. * Eligible for bariatric surgery. * Willingness to provide informed consent and willingness to participate and comply with the study requirements Exclusion Criteria: * Unable to undertake MRI due to size restrictions i.e., shoulder width more than 70 cm. * History or clinical manifestation of any other significant metabolic, hematologic, pulmonary, cardio- vascular, gastrointestinal, neurologic, immune, hepatic, renal, urologic, muscular, and joint disorders, or cancer that, in the opinion of the investigator, would make the candidate ineligible for the study. For example, significant joint pain could interfere with adherence to the exercise program. * Have objectively assessed cognitive impairment as assessed by the Montreal Cognitive Assessment (MoCA) i.e., total score less than 26. * Non-MRI-compatible implanted devices or implants. * Inability to exercise via supine ergometer. * Claustrophobia. * Psychiatric or behavioural problems (history of drug and alcohol abuse, eating disorder). * Breastfeeding or pregnant women, or those intending to become pregnant before the scheduled end of the intervention. * Unwilling to be assigned at random to the exercise or control intervention. * Unwilling or unable to adhere to the rigors of the exercise intervention or evaluation schedule over the entire one-year period. * Concurrent participation in any other interventional study.