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SMS 2: Impact of Cancer Therapy on the Somatic Mutational Landscape of Normal Tissues
Sponsor: The Wellcome Sanger Institute
Summary
Recently technology has been developed at the Wellcome Sanger Institute to allow clusters of cells with mutations to be detected in normal and diseased tissues. The researchers wish to determine how the number and nature of these mutant cell clusters change in response to treatments given to cancer patients (such as chemotherapy, radiotherapy, immunotherapy, and drugs targeted at specific mutations in tumours). As such the researchers wish to collect research samples of blood, cheek cells (via swabs) and urine from adult cancer patients receiving the above-mentioned treatments as part of their standard care. The researchers also wish to access any leftover tissue following surgery that is undertaken as part of these patient's treatment.
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2024-11-26
Completion Date
2029-05-13
Last Updated
2025-02-18
Healthy Volunteers
No
Conditions
Interventions
sample collection
Participants may collected their own cheek swabs and will collect their own urine samples. Clinical professionals at participating sites will collect blood samples.
Discussing study
Research Nurse/ Suitably qualified Research Site Staff will discuss the study with potential participants
Seeking consent
Potential participants who wish to give consent will do with a Research Nurse/ Suitably qualified Research Site Staff.
Locations (1)
Wellcome Sanger Institute
Cambridge, United Kingdom