Clinical Research Directory

Clinicaly Manifested Reinfections with Borrelia Burgdorferi Sensu Lato

Sponsor: University Medical Centre Ljubljana

Summary

Data on reinfections with B. burgdorferi sensu lato in humans are scarce; they are limited to case reports and a few small groups of patients, mostly from the USA and less frequently from Europe. In these reports, the clinical manifestation of reinfection was usually erythema migrans and was most often documented after successful treatment of a previous infection (almost always erythema migrans). The clinical manifestations of Lyme disease in reinfection appear to be similar to those of primary infection, but there are no studies on possible differences in serological or immunological responses. The current study has 3 primary objectives: * To determine the frequency of clinically detectable reinfections and to identify the circumstances under which they occur; * To determine possible differences between primary and reinfection in clinical presentation, disease course and outcome, and specific serum antibody response; * To determine the aetiology of clinically detectable reinfections by comparing Borrelia isolates recovered from the skin of the same patient at primary and reinfection.

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