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Amino Acid Supplementation in Continuous Renal Replacement Therapy
Sponsor: Karolinska University Hospital
Summary
ICU patients treated with continuous renal replacement therapy is recruited prior to start of treatment. Blood samples are drawn and then dialysis start without amino acid supplementation. After a few hours samples are drawn from blood and dialysate. Then patients are given amino acid supplementation (33.5g/24hrs) for 20-24 hours. New samples are drawn and amino acid supplementation is increased to 67g/24hrs and new samples are drawn after additional 24 hours. Then CRRT will continue with the full amino acid supplementation (standars of care).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-02-03
Completion Date
2028-12-31
Last Updated
2025-02-19
Healthy Volunteers
No
Conditions
Interventions
Amino acid supplementation (Glavamin, Fresenius Kabi)
Mixture of amino acids (67 g / 500 ml) given intravenously
Locations (1)
Karolinska University Hospital
Stockholm, Sweden