A Multicenter Study on Atrioventricular Regurgitation in Transthyretin Amyloid Cardiomyopathy: Definition, Prevalence, and Prognostic Impact.

RECRUITING

NCT06836011

Sponsor: Medical University of Vienna

Summary

The objective of this prospective registry study is to comprehensively characterize the prevalence, (semi-) quantitative parameters, and associated clinical outcomes of mitral (MR) and tricuspid regurgitation (TR) in patients diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM). The study further aims to develop and implement new grading standards for the quantitative assessment of regurgitation severity, tailored to the distinct hemodynamic profile of ATTR-CM. This approach seeks to address the limitations of current regurgitation severity classifications, which do not adequately reflect the unique pathophysiology of a restrictive phenotype as seen in ATTR-CM.

Official title: Definition and Prognosis of Atrioventricular Regurgitation in Transthyretin Amyloid Cardiomyopathy - a Prospective International Multicenter Study

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

600

Start Date

2025-01-01

Completion Date

2026-12-31

Last Updated

2025-02-19

Healthy Volunteers

No

Conditions

ATTR Amyloidosis With Cardiomyopathy ATTR-CM ATTR Amyloidosis Wild Type Mitral Regurgitation Tricuspid Regurgitation

Locations (8)

Medical University of Graz

Graz, Styria, Austria

Department of Internal Medicine II, Medical University of Vienna

Vienna, Austria

Medizinische Klinik und Poliklinik I, Klinikum der Universitaet Muenchen, Ludwig-Maximilians-University

Munich, Bavaria, Germany

Department of Cardiology, University Hospital Frankfurt, Goethe University

Frankfurt am Main, Hesse, Germany

Institute of Cardiology, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia

Brescia, Italy

Cardiologic Centre, Azienda Ospedaliero Universitaria di Ferrara

Ferrara, Italy

Center for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste

Trieste, Italy

University Medical Center Utrecht

Utrecht, Netherlands

Clinical Research Directory