Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
RECRUITING
NCT06836830
NA

PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest

Sponsor: Muehlenkreiskliniken, MKK

View on ClinicalTrials.gov

Summary

Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.

Official title: Peri-Arrest Ventilation With Positive End-Expiratory-Pressure vs. Zero End-Expiratory-Pressure in Out-of-Hospital-Cardiac-Arrest

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

600

Start Date

2025-06-01

Completion Date

2026-10-31

Last Updated

2025-08-06

Healthy Volunteers

No

Interventions

PROCEDURE

PEEP 5 mbar

Positiv-End-Expiratory Pressure

PROCEDURE

ZEEP 0 mbar

Zero-End-Expiratory Pressure

Locations (3)

Emergency Medical Services

Gütersloh, North Rhine-Westphalia, Germany

JWK Minden

Minden, North Rhine-Westphalia, Germany

Emergency Medical Services

Osnabrück, Germany