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PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest
Sponsor: Muehlenkreiskliniken, MKK
Summary
Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.
Official title: Peri-Arrest Ventilation With Positive End-Expiratory-Pressure vs. Zero End-Expiratory-Pressure in Out-of-Hospital-Cardiac-Arrest
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
600
Start Date
2025-06-01
Completion Date
2026-10-31
Last Updated
2025-08-06
Healthy Volunteers
No
Interventions
PEEP 5 mbar
Positiv-End-Expiratory Pressure
ZEEP 0 mbar
Zero-End-Expiratory Pressure
Locations (3)
Emergency Medical Services
Gütersloh, North Rhine-Westphalia, Germany
JWK Minden
Minden, North Rhine-Westphalia, Germany
Emergency Medical Services
Osnabrück, Germany