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NOT YET RECRUITING
NCT06837051
NA

The Effect of Modified Olfactory Training on Postoperative Olfactory Dysfunction in Patients With CRS

Sponsor: Peking University Third Hospital

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can treat postoperative olfactory dysfunction in patients with chronic sinusitis? Compared to the conventional device, how efficient is the modified olfactory training device for treating postoperative olfactory dysfunction in patients with chronic sinusitis?

Official title: Protocol for a Randomized Controlled Trial Evaluating the Effect of Modified Olfactory Training on Postoperative Olfactory Dysfunction in Patients With Chronic Rhinosinusitis

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

213

Start Date

2025-03-14

Completion Date

2027-03-14

Last Updated

2025-02-20

Healthy Volunteers

No

Interventions

DEVICE

Conventional olfactory training device

Four odorants are used: phenyl ethyl alcohol (PEA): rose, menthol: mint, citronellal: lemon, and eugenol: cloves. Training patients will receive four glass vials. Each contains one odorant (5 mL, soaked in cotton pads to prevent spilling) and is labeled with the name of the odorant. Budesonide irrigation can effectively target the olfactory cleft area to provide anti-inflammatory effects.

DEVICE

Modified olfactory training device

The modified olfactory training device is based on the nasal bidirectional drug delivery system. The device uses breathing pressure to create positive pressure, significantly increasing the deposition rate of odors in the olfactory cleft area. Budesonide irrigation can effectively target the olfactory cleft area to provide anti-inflammatory effects.

DRUG

Budesonide irrigation

Budesonide irrigation can effectively target the olfactory cleft area to provide anti-inflammatory effects.

Locations (1)

Beijing

Beijing, Beijing Municipality, China