Clinical Research Directory

Inclusion Criteria: * Subjects must meet all of the following inclusion criteria to enter the study: 1. Clinically diagnosed with gastroptosis; 2. Meets the diagnostic criteria for malnutrition (fulfilling any one of the following two criteria): * Weight loss (weight loss \>5% within the last 6 months or \>10% over more than 6 months); * Low BMI (BMI \<18.5 kg/m² for individuals \<70 years old; BMI \<20 kg/m² for individuals ≥70 years old); 3. Males aged ≥18 years and non-pregnant, non-lactating females aged ≥18 years; 4. Willing to voluntarily sign a written informed consent form and agrees to follow medical advice for regular follow-up examinations and monitoring after the completion of treatment. Exclusion Criteria: * Subjects meeting any of the following exclusion criteria must be excluded from the study: 1. Patients with severe depression, anxiety, or cognitive impairment that affects normal physician-patient communication and treatment planning; 2. Patients with poor compliance who cannot accept treatment regimens such as nasogastric enteral nutrition; 3. Anticipated survival time \<3 months; 4. Clinically significant cardiovascular diseases, including heart failure (NYHA Class III-IV), uncontrolled coronary artery disease, cardiomyopathy, arrhythmia, history of myocardial infarction, hemodynamic instability at enrollment, unstable vital signs, or anticipated risk events during treatment; 5. Poor pulmonary function deemed by investigators to impact study treatment (e.g., acute exacerbation of COPD or requirement for long-term oral/intravenous corticosteroids \[excluding inhaled corticosteroids\]); 6. Active severe clinical infections (\> Grade 2 per NCI-CTCAE v5.0), including patients with intestinal fungal, viral, or tuberculosis infections; 7. Inability to cooperate with intestinal tube placement or contraindications to intestinal tube placement; 8. Use of medications affecting or modulating gut microbiota within the past 48 hours; 9. Lack of legal capacity or restricted legal capacity; 10. Hematologic disorders unsuitable for blood draw examinations; 11. Other severe medical conditions deemed by investigators to preclude patient enrollment.