Clinical Research Directory

Inclusion Criteria: * Adult ≥ 18 years of age, males and females. * Left Ventricular Ejection Fraction (LVEF) ≥ 50%. * Symptoms and/or signs of heart failure. * H2FPEF score ≥ 6 points or HFA-PEFF score ≥ 5 points. * N-terminal pro-B-type natriuretic peptide (NT-proBNP) ≥125 pg/mL at baseline (patients with atrial fibrillation at baseline NT-proBNP ≥365 pg/mL), or objective evidence of systemic or pulmonary congestion. * Stable medical therapy within the last 1 month. Exclusion Criteria: * Patients requiring colchicine for other conditions or with a history of colchicine intolerance or hypersensitivity. * Active or chronic inflammatory diseases or infection. * Presence of active solid tumors or hematological malignancies. * Estimated glomerular filtration rate (eGFR) \<35 mL/min/1.73 m². * Severe liver disease includes Child-Pugh class B or C, cirrhosis, or chronic active hepatitis. * Concurrent use of strong CYP3A4 or P-glycoprotein inhibitors. * Presence of blood dyscrasias. * Recent major cardiovascular events or procedures within the last 3 months. * Established diagnosis of pericardial disease, myocarditis, hypertrophic cardiomyopathy, and cardiac amyloidosis * Significant valvular heart disease. * Lack of informed consent.