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Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain
Sponsor: Mayo Clinic
Summary
The purpose of this study is to determine whether exposure to prescription opioids is associated with brain structural changes on magnetic resonance imaging (MRI), with the primary outcome of white matter integrity as measured by fractional anisotropy of the corpus callosum.
Official title: Imaging, Cognition, and Opioids in Older Adults With Chronic Pain (I-COAP) Trial
Key Details
Gender
All
Age Range
65 Years - Any
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2025-04-16
Completion Date
2029-12-31
Last Updated
2026-01-08
Healthy Volunteers
No
Conditions
Interventions
Opioid
Subjects will receive oral oxycodone as needed for pain which will be titrated weekly based on pain response, adverse effects, and patient preference. Subjects with intolerance to oxycodone will receive the equivalent dosing of morphine as an alternative.
Opioid Placebo
Subjects will receive a placebo capsule identical to oxycodone, which will similarly be titrated weekly. Subjects with intolerance to the first placebo will receive another placebo capsule identical to morphine.
Locations (1)
Mayo Clinic in Rochester
Rochester, Minnesota, United States