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Follicular Volume at the Time of Final Oocyte Maturation in Poor Responders, and Its Correlation With Oocyte Maturity
Sponsor: ART Fertility Clinics LLC
Summary
Women with a severely diminished ovarian reserve and monofollicular growth are at a higher risk of premature ovulation as well as poor quality oocytes. Our group showed previously that women with severely diminished ovarian reserve benefit from receiving the final oocyte maturation at smaller follicle sizes in terms of reducing the risk of premature ovulation and finding mature oocytes even out of small size follicles. Adding the measurement of the follicular volume at the time of final oocyte maturation might provide more information on the proper timing of trigger administration compared to the follicular size alone, hormonal profile as well as previous stimulation attempts. Setting a cutoff value of follicular volume for trigger might help to avoid premature ovulation and possibly increase the chances of ending up with a euploid embryo.
Key Details
Gender
FEMALE
Age Range
18 Years - 48 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2025-03-27
Completion Date
2025-12-31
Last Updated
2025-04-09
Healthy Volunteers
Yes
Conditions
Interventions
transvaginal Ultrasound
The only additional measure will be the measurement of the follicle volumes on the day of trigger and before oocyte pick up procedure. This will be performed at the same time as the pre Oocyte pick up ultrasound prior to the patient admission to the recovery room for preparation. The ultrasound that will be used already has a pre build program that calculates the follicular volume automatically and hence not extending the ultrasound time.
Locations (1)
ART Fertility Clinics
Abu Dhabi, Abu Dhabi Emirate, United Arab Emirates