Clinical Research Directory

Inclusion Criteria: 1. Patients with clinical signs of acute ischemic stroke within 24 hours of onset or awakening with stroke (if within 24 hours from the midpoint of sleep). Patients with AIS within 4.5-24 hours of onset must meet the IVT inclusion criteria specified in the guideline 2. Patients with prior ischemic stroke within 3 months 3. Patients ≥ 18 years old 4. Informed consent has been obtained depending on local ethics requirements. Exclusion Criteria: (1) Plan to receive endovascular treatment (2) Pre-stroke mRS score \> 2 (3) Contraindications for IVT： 1. Intracranial hemorrhage (including parenchymal hemorrhage, intraventricular hemorrhage, subarachnoid hemorrhage, epidural hematoma, etc.) 2. Previous history of intracranial hemorrhage 3. Severe head trauma or stroke history within the last 3 months 4. Intracranial tumors, giant intracranial aneurysms 5. Intracranial or spinal surgery within the recent 3 months 6. Major surgical procedures within the last 2 weeks 7. Gastrointestinal or urinary tract bleeding within the last 3 weeks 8. Active visceral bleeding 9. Aortic arch dissection 10. Arterial puncture in a site within the last 1 week that is not easy to compress and stop bleeding 11. Elevated blood pressure: Systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 100 mmHg 12. Acute bleeding tendency, including platelet count \< 100 × 10⁹/L or other conditions 13. Received low-molecular-weight heparin treatment within 24 hours 14. Oral anticoagulants (warfarin) with INR \> 1.7 or PT \> 15 s; Receiving heparin treatment with aPTT above the upper limit of the normal range within the last 24 hours of onset, Receiving thrombin inhibitors and factor Xa inhibitors within the last 48 hours of onset. 15. Blood sugar \< 2.8 or \> 22.22 mmol/L 16. Head CT or MRI indicates large-area infarction (infarction area ≥ 1/3 of the middle cerebral artery supply area) (4) The judgment is left to the discretion of the investigator