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A Study to Improve Skeletal Muscle in Veterans With HIV
Sponsor: VA Office of Research and Development
Summary
The Department of Veterans Affairs is the largest single provider of medical care to people with HIV in the United States. The condition of excess lipid within and around muscle, termed myosteatosis, predisposes Veterans to physical function decline, frailty, disability, and cardiometabolic diseases such as diabetes and cardiovascular disease. In the investigators current Merit supported cohort, the investigators found that 36% of Veterans with treated HIV and obesity have "myosteatotic type obesity". Based on the investigators findings, the investigators have designed a multipronged integrated intervention that combines: 1) dietary replacement of saturated with unsaturated fats; 2) administration of L-carnitine and omega-3 fatty acid supplementation; and 3) targeted resistance exercise training.
Official title: A Randomized Trial to Optimize Skeletal Muscle While Reducing Adiposity in Veterans With HIV
Key Details
Gender
MALE
Age Range
20 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2025-07-15
Completion Date
2029-06-29
Last Updated
2025-07-30
Healthy Volunteers
No
Interventions
w-3 fatty acid
omega-3 fatty acid supplement
L-carnitine
L-carnitine supplement
Control Diet
Control Diet high in unsaturated fat
Locations (1)
Tennessee Valley Healthcare System Nashville Campus, Nashville, TN
Nashville, Tennessee, United States