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RECRUITING
NCT06846320
PHASE2

Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder

Sponsor: AbbVie

View on ClinicalTrials.gov

Summary

Generalized anxiety disorder (GAD) is usually treated with antidepressant therapy (ADT); however, sometimes ADTs alone are not enough to adequately treat GAD. The purpose of this study is to assess how safe and effective ABBV-932 is when added to the antidepressant therapies in adult participants with GAD who have had an inadequate response ADTs. ABBV-932 is an investigational drug being developed for the adjunctive treatment of GAD. Participants will be randomly assigned to receive ABBV-932 or Placebo in addition to their currently prescribed ADTs. There is 1 in 3 chance of participants assigned to Placebo. Approximately 315 adult participants with GAD and inadequate response to ADTs will be enrolled in approximately 50 sites in the United States and Puerto Rico. Participants will receive oral capsules of ABBV-932 or matching placebo in addition to their prescribed ADT for 6 weeks and then will be followed for an additional 4 week follow-up period. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.

Official title: A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Fixed-Dose Study to Evaluate the Efficacy, Safety, and Tolerability of ABBV-932 as an Adjunct to Antidepressant Therapies in the Treatment of Subjects With Generalized Anxiety Disorder Who Have Had an Inadequate Response to Antidepressant Therapies

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

315

Start Date

2025-04-29

Completion Date

2026-11

Last Updated

2026-01-23

Healthy Volunteers

No

Interventions

DRUG

ABBV-932

Oral Capsule

DRUG

Placebo for ABBV-932

Oral Capsule

DRUG

Antidepressant Therapy (ADT)

Standard of care

Locations (52)

University of Alabama - Huntsville Regional Medical Campus /ID# 267818

Huntsville, Alabama, United States

Ima Clinical Research Phoenix (Alea) /ID# 275737

Phoenix, Arizona, United States

Noble Clinical Research /ID# 267952

Tucson, Arizona, United States

Advanced Research Center /ID# 267874

Anaheim, California, United States

Axiom Research /ID# 267814

Colton, California, United States

Sun Valley Research Center /ID# 267864

Imperial, California, United States

Synergy San Diego /ID# 267879

Lemon Grove, California, United States

Alliance for Research Alliance for Wellness /ID# 267911

Long Beach, California, United States

NRC Research Institute DTLA /ID# 267832

Los Angeles, California, United States

Excell Research /ID# 267918

Oceanside, California, United States

Viking Clinical Research Center - Temecula /ID# 268598

Temecula, California, United States

Sunwise Clinical Research /ID# 267863

Walnut Creek, California, United States

Connecticut Clinical Research - Cromwell /ID# 271241

Cromwell, Connecticut, United States

Cns Healthcare - Jacksonville /ID# 268588

Jacksonville, Florida, United States

Accel Research Sites Network - St. Pete /ID# 267821

Largo, Florida, United States

K2 Medical Research, LLC /ID# 267841

Maitland, Florida, United States

GMI Florida - Central Miami Medical Institute /ID# 267839

Miami, Florida, United States

Allied Biomedical Res Inst Inc /ID# 267813

Miami, Florida, United States

Apg Research /ID# 271707

Orlando, Florida, United States

Psych Atlanta /ID# 267878

Marietta, Georgia, United States

iResearch Savannah /ID# 267865

Savannah, Georgia, United States

University of Chicago Medical Center /ID# 275131

Chicago, Illinois, United States

Collective Medical Research /ID# 272015

Overland Park, Kansas, United States

CenExel /ID# 267853

Gaithersburg, Maryland, United States

Elixia, LLC /ID# 267815

Springfield, Massachusetts, United States

Psychiatric Care And Research Center /ID# 271701

O'Fallon, Missouri, United States

St. Charles Psychiatric Associates /ID# 271202

Saint Charles, Missouri, United States

Arch Clinical Trials /ID# 267851

St Louis, Missouri, United States

Ima Clinical Research Las Vegas (Altea) /ID# 275731

Las Vegas, Nevada, United States

Duplicate_Oasis Clinical Research, LLC /ID# 267953

Las Vegas, Nevada, United States

Princeton Medical Institute /ID# 267877

Princeton, New Jersey, United States

Bio Behavioral Health /ID# 267919

Toms River, New Jersey, United States

Integrative Clinical Trials /ID# 279519

Brooklyn, New York, United States

New Hope Clinical Research - Inpatient unit /ID# 267810

Charlotte, North Carolina, United States

Quest Therapeutics of Avon /ID# 267829

Avon Lake, Ohio, United States

University Of Cincinnati Medical Center /ID# 271704

Cincinnati, Ohio, United States

The Ohio State University /ID# 267924

Columbus, Ohio, United States

Sooner Clinical Research /ID# 267881

Oklahoma City, Oklahoma, United States

Lehigh Center for Clinical Research /ID# 267908

Allentown, Pennsylvania, United States

Suburban Research Associates /ID# 267868

West Chester, Pennsylvania, United States

Coastal Carolina Research Center, LLC /ID# 267826

Charleston, South Carolina, United States

Psychiatric Consultants - Franklin /ID# 275133

Franklin, Tennessee, United States

FutureSearch Trials of Dallas /ID# 267870

Dallas, Texas, United States

Relaro Medical Trials /ID# 270241

Dallas, Texas, United States

Perceptive Pharma Research /ID# 267836

Richmond, Texas, United States

Family Psychiatry Of The Woodlands /ID# 275173

The Woodlands, Texas, United States

Grayline Research Center /ID# 267811

Wichita Falls, Texas, United States

Northwest Clinical Research Center /ID# 267916

Bellevue, Washington, United States

Core Clinical Research /ID# 270058

Everett, Washington, United States

INSPIRA Clinical Research /ID# 267822

San Juan, Puerto Rico

Instituto De Neurologia Dra. Ivonne Fraga, Psc /ID# 267793

San Juan, Puerto Rico

BDH Research /ID# 267787

San Juan, Puerto Rico