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ENROLLING BY INVITATION
NCT06846814

Second-Look Ultrasound Post Contrast-Enhanced Mammography for Additional Lesions Characterization

Sponsor: Graziella di Grezia

View on ClinicalTrials.gov

Summary

This study investigates the utility of second-look ultrasound (US) following contrast-enhanced mammography (CEM) to characterize additional lesions detected during routine breast imaging.

Key Details

Gender

FEMALE

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

350

Start Date

2025-01-01

Completion Date

2026-01-31

Last Updated

2025-02-26

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

CEM protocol

The intervention consists of Second-Look Ultrasound (SLUS) performed following Contrast-Enhanced Mammography (CEM) to further evaluate additional lesions detected during routine breast imaging. When CEM identifies additional or suspicious lesions not clearly characterized by mammography alone, targeted ultrasound is conducted to assess lesion morphology, vascularity, and acoustic characteristics. Radiologists with expertise in both CEM and ultrasound interpretation will perform SLUS to determine whether the lesions require biopsy, short-term follow-up, or no further action. Findings will be correlated with histopathological results (if biopsy is performed) or follow-up imaging to assess diagnostic accuracy.

Locations (1)

University of Campania Luigi Vanvitelli

Naples, Italy