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Real-world Effectiveness and Safety of Trastuzumab Deruxtecan in Patients With Locally Advanced or Metastatic HER2-positive Gastric or Gastroesophageal Junction Adenocarcinoma in China
Sponsor: Daiichi Sankyo
Summary
Trastuzumab deruxtecan's (T-DXd's) efficacy and safety has been confirmed in traditional clinical trials, there is a lack of real-world evidence, especially among Chinese patients. The objective of this study is to evaluate real-world effectiveness and safety profile of T-DXd by collecting real-world data treating in patients with locally advanced or metastatic HER2-positive gastric or gastroesophageal junction adenocarcinoma.
Official title: Real-world Effectiveness and Safety of Trastuzumab Deruxtecan in Patients With Locally Advanced or Metastatic HER2-positive Gastric or Gastroesophageal Junction Adenocarcinoma in China: A Nation-wide, Multi-center, Prospective, Non-interventional Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
260
Start Date
2025-02-27
Completion Date
2027-07-31
Last Updated
2025-07-08
Healthy Volunteers
No
Interventions
Trastuzumab deruxtecan (T-DXd)
This is an non-interventional, observational study. No drug will be provided or administered as part of this protocol; however, participants on T-DXd (starting dose 6.4 mg/kg IV Q3W) will be enrolled in this study as part of clinical routine or the clinical judgement of physician.
Locations (36)
China-Japan Friendship Hospital
Beijing, China
Peking Union Medical College Hospital
Beijing, China
Peking University First Hospital
Beijing, China
Beijing Cancer Hospital
Beijing, China
Beijing GoBroad Hospital
Beijing, China
The First Hospital of Jilin University
Changchun, China
Changzhi People's Hospital
Changzhi, China
Fujian Cancer Hospital
Fuzhou, China
Guangdong Provincial People's Hospital
Guangzhou, China
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, China
Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Guangzhou, China
Guangdong Hospital of Traditional Chinese Medicine
Guangzhou, China
Hainan General Hospital
Haikou, China
Zhejiang Cancer Hospital
Hangzhou, China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hangzhou, China
The Second Affiliated Hospital Zhejiang University School of Medicine
Hangzhou, China
Anhui Province Cancer Hoospital
Hefei, China
Jiangmen Central Hospital
Jiangmen, China
Nanjing Drum Tower Hospital
Nanjing, China
Jiangsu Cancer Hospital
Nanjing, China
Shanghai GoBroad Cancer Hospital
Shanghai, China
Shanghai ninth People's Hospital,Shanghai Jiaotong University School of Medicine
Shanghai, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, China
Zhongshan Hospital
Shanghai, China
Huadong Hospital Affiliated to Fudan University
Shanghai, China
Cancer Hospital of Shantou University Medical College
Shantou, China
Liaoning Cancer Hospital
Shenyang, China
Shanxi Cancer Hospital
Taiyuan, China
Taizhou Hospital of Zhejiang Province
Taizhou, China
Tianjin Medical University Cancer Institute and Hospital
Tianjin, China
The Second Hospital of Tianjin Medical University
Tianjin, China
The Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
The Affiliated Hospital of Xiamen University
Xiamen, China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, China
Henan Cancer Hospital
Zhengzhou, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, China