Clinical Research Directory

Inclusion Criteria: 1. Meet the Rome IV diagnosis criteria for chronic constipation; 2. Patients who are able to understand clinical studies and are committed to complying with study requirements and procedures; 3. Age 18-65. - Exclusion Criteria: 1. Systemic (diabetes, autoimmune diseases, cancer), gastrointestinal or liver diseases known to be associated with alterations in the gut microbiota; 2. Patients who are pregnant or lactating; 3. have taken antimicrobials, probiotics, or drugs that inhibit stomach acid or gastrointestinal motility in the past 6 weeks; 4. Patients who changed their diet type during the study; 5. Patients who are allergic or intolerant to any component of the investigational product formulation; 6. Patients with cardiovascular, cerebrovascular, liver, kidney and hematopoietic system and other serious diseases and endocrine diseases, mental patients; 7. Stop taking the tested sample or add other drugs in the middle, unable to judge the efficacy or incomplete data; 8. short-term use of objects related to the function of the test, affecting the judgment of the result; 9. have been dieting, exercising excessively, taking weight loss medications or taking medications that may affect appetite in the past 3 months; 10. Current or past excessive use of alcohol, drugs, or supplements that may cause intestinal dysfunction or interfere with the evaluation of the efficacy of the study product -