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Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders
Sponsor: University of Pennsylvania
Summary
The research study is being conducted to better understand parts of the human brain called the cortex, basal ganglia, thalamus, and cerebellum in patients with movement disorders (such as Parkinson's disease, essential tremor, dystonia, or ataxia). These brain structures are involved in movement disorders. This study attempts to better understand the brain electrical activity associated with these disorders, both in patients with and without deep brain stimulation (DBS). Recordings are made from the scalp with a noninvasive electrode and/or through the DBS stimulator if the participant has a stimulator model that is able to sense brain activity. These recordings are analyzed along with measures of movement disorder symptoms to identify brain signal signatures of symptoms.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2025-12-10
Completion Date
2030-04
Last Updated
2026-03-11
Healthy Volunteers
No
Conditions
Interventions
Prescribed Medications
participant's movement disorders medications, prescribed by their treating physician
Deep brain stimulation adjustment
Deep brain stimulator parameters may be adjusted within normal clinical limits
Locations (1)
Pennsylvania Hospital
Philadelphia, Pennsylvania, United States