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Mg Sulfate Versus Dexmedetomidine on Cerebral Oxygen Saturation
Sponsor: Tanta University
Summary
This study is to evaluate the effects of dexmedetomidine and magnesium sulfate on cerebral oxygen saturation in patients undergoing spine surgeries as adjuvant to general anesthesia guided by cerebral oximetry. The main aims to are Incidence of cerebral desaturation events and duration of cerebral desaturation events.
Official title: Effects of Dexmedetomidine Versus Magnesium Sulfate on Cerebral Oxygen Saturation During Spine Surgery: a Prospective Randomized Controlled Study
Key Details
Gender
All
Age Range
21 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2025-02-23
Completion Date
2027-01-31
Last Updated
2025-02-27
Healthy Volunteers
No
Interventions
spine surgery
spine surgery in prone position
Magnesium sulfate
Patients will receive loading dose of 40 mg/kg of magnesium sulfate diluted in 50 ml of 0.9% saline IVI will be given in 10 min before anesthesia induction then continuous infusion of 10 mg/kg/hour during the surgery.
Dexmedetomidine
Patients will receive loading dose of 1 mcg/kg dexmedetomidine diluted in 50 ml of saline 0.9% IVI will be given in 10 min before anesthesia induction then continuous infusion of 0.5 mcg/kg/hour during the surgery.
Normal Saline (0.9% NaCl)
Patients will receive the same volume of normal saline.