Clinical Research Directory

Inclusion Criteria: 1. PD patients who meet the diagnostic criteria of the International Movement Disorders Association (MDS), between the ages of 50 and 70 years, the course of disease ≤5 years, and the Hoehn \& Yahr stage ≤3; 2. Anti-PD drugs were taken regularly for at least one month before screening, and symptoms were stable; 3. The fixed bedtime in the past month is between 9:00 p.m. and 1:00 a.m., and the total sleep time is ≥6 hours; 4. Have the ability to understand and voluntarily sign informed consent; 5. Have good compliance and are willing to complete all follow-up required by this program. Exclusion Criteria: 1. Secondary insomnia: including sleep disorders (restless leg syndrome, periodic limb movement disorder, sleep-related breathing disorders, etc.), physical diseases, mental disorders, psychoactive substance abuse; 2. suffering from photosensitive dermatitis, epilepsy and other diseases that are not suitable for flash stimulation; 3. Alcohol, coffee, or drug abusers in the past 6 months; 4. Mental illness: such as anxiety, depression, schizophrenia and post-traumatic stress disorder caused by insomnia; 5. Used drugs or health products that regulate sleep function or affect sleep within 14 days before enrollment or less than 5 drug half-lives; 6. Taking drugs that may impair cognitive ability, such as anticholinergic drugs, memory enhancing drugs, etc., within 7 days before enrollment; 7. the subject is unable to complete the test or follow-up; 8. suffering from other neurodegenerative diseases; 9. There are endoplants in the body that cannot be examined by MRI; 10. Inability to lie flat; 11. Other situations in which the researcher considers it inappropriate to participate in the study.