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Comparison of Oxcarbazepine Versus Carbamazepine in the Management of Trigeminal Neuralgia
Sponsor: Jinnah Postgraduate Medical Centre
Summary
Trigeminal neuralgia is a debilitating neurological condition, affecting quality of life in most affected patients. Carbamazepine has traditionally been used for the management of this condition, but it has a moderate effectiveness and a poor side-effect profile. Oxcarbazepine is more tolerable, and has a more favorable side-effect profile. This study aims to compare the effectiveness of oxcarbazepine and carbamazepine in the management of this condition, for improved prescription practices in the future.
Official title: Comparison of Oxcarbazepine Versus Carbamazepine in the Management of Trigeminal Neuralgia in Patients Presenting in Outpatient Department of Neurology in Jinnah Postgraduate Medical Centre
Key Details
Gender
All
Age Range
25 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
122
Start Date
2024-09-21
Completion Date
2025-03-21
Last Updated
2025-03-04
Healthy Volunteers
No
Conditions
Interventions
Oxcarbazepine
Oxcarbazepine will be started at a dose of 150 mg BD, and follow-up will be done every month. Dose will be titrated up if minimal pain relief, to a maximum dose of 1800 mg per day.
Carbamazepine
Carbamazepine will be started at a dose of 100 mg BD, and follow-up will be done every month. Dose will be titrated up if minimal pain relief, to a maximum dose of 1200 mg per day.
Locations (1)
Jinnah Postgraduate Medical Centre
Karachi, Sindh, Pakistan